I-Endemic ibhekisa kuhlobo lwesityalo okanye lwesilwanyana esikhethekileyo nesikhethekileyo kwindawo ethile okanye indawo ethile.. Iintlobo ze-endemic zifumaneka kuphela kwindawo ethile kwaye azifumaneki kwenye indawo emhlabeni.
Oku kunokwenzeka ngenxa yezizathu ezininzi, kubandakanywa nokwakheka komhlaba, imozulu, kunye nemiba ye-ikholoji edala imeko-bume eyodwa efanele ukuphila kunye nokwanda kohlobo oluthile. Ukwahlukaniswa kweminye imimandla kunokukhokelela ekuphuhlisweni kweempawu zofuzo ezizodwa kunye nohlengahlengiso kwiintlobo ezivumela ukuba zikhule kwindawo ethile..
Iintlobo ezihlala zikho zisoloko zithathwa njengezinexabiso eliphezulu lolondolozo, njengoko bemele indawo ekhethekileyo yendalo eyahlukeneyo kunye nenkqubo yendalo. Basenokuba sengozini yokulahlekelwa yindawo yokuhlala, imo iyatshintsha, okanye ezinye izinto zokusingqongileyo, nto leyo enokuphumela ekuncipheni kwabemi okanye kwanokuphela.
Imizekelo yeentlobo ezihlala zikho ziquka ufudo olukhulu lweGalapagos, efumaneka kuphela kwiiGalapagos Islands ezikunxweme lwase-Ecuador, kunye nentaba yepygmy possum, efumaneka kuphela kwimimandla yealpine ekumzantsi-mpuma weOstreliya.